Chromosome Aberrations Induced in Human Lymphocytes by D-T Neutrons
- 1 June 1984
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 98 (3), 561-573
- https://doi.org/10.2307/3576488
Abstract
Unstable chromosome aberrations induced by in vitro irradiation with D-T [deuterium-tritium] neurons were analyzed in human blood lymphocyts. With respect to 250 kVp [kilovolt peak] X-rays, a maximum limiting RBE [relative biological effectiveness] at low doses of 4.1 was obtained for dicentric aberrations. Using aberrations as markers in mixed cultures of irradiated and unirradiated cells permits an assessment of interphase death plus mitotic delay. The low-dose RBE for this effect is 2.5. Assuming all unstable aberrations observed at metaphase would lead to cell death by nondisjunction allows an assessment of mitotic death. The low-dose RBE for this effect is 4.5. The data are compared with similar work obtained earlier with 242Cm .alpha. particles. The application of the present work to cytogenetic assessment of dose after accidental exposure to D-T neutrons is discussed.This publication has 6 references indexed in Scilit:
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