(S)-β,ω-Dihydroxyalkyl Phenyl Sulfones. Synthesis by Bakers Yeast Reduction and Use as Precursors of Optically Active Lactones
- 5 September 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 17 (9), 1537-1540
- https://doi.org/10.1246/cl.1988.1537
Abstract
The enantioselective reduction of ω-hydroxy-β-ketoalkyl phenyl sulfones with bakers’ yeast gives (S)-ω,β-dihydroxyalkyl phenyl sulfones, which are convenient precursors for optically active lactones as shown in the synthesis of (R)-4-hexanolide and (R)-umbelactone.Keywords
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