The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8
- 1 November 1991
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 17 (6), 609-615
- https://doi.org/10.1007/bf01233626
Abstract
The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse × Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal toLHRH, and two (LPL, DEF1) lie distal toLHRH. The localization ofGnrh, the murine homolog ofLHRH, to mouse chromosome 14 therefore defines a hitherto unrecognized block of homology between man and mouse. Furthermore, it indicates that the region of homology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.Keywords
This publication has 20 references indexed in Scilit:
- Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellitesNucleic Acids Research, 1990
- The Hypogonadal Mouse: Reproductive Functions Restored by Gene TherapyScience, 1986
- A Deletion Truncating the Gonadotropin-Releasing Hormone Gene Is Responsible for Hypogonadism in the hpg MouseScience, 1986
- Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.Proceedings of the National Academy of Sciences, 1986
- Human Luteinizing hormone-releasing hormone gene (LHRH) is located on short arm of chromosome 8 (region 8p11.2 → p21)Somatic Cell and Molecular Genetics, 1986
- A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormoneNature, 1985
- Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadismNature, 1977
- Primary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF)Proceedings of the National Academy of Sciences, 1972
- Gonadotropin-Releasing Hormone: One Polypeptide Regulates Secretion of Luteinizing and Follicle-Stimulating HormonesScience, 1971
- Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequenceBiochemical and Biophysical Research Communications, 1971