The determination of m-tyrosine in human plasma by high performance liquid chromatography.

Abstract

A fluorometric detector and a voltammetric detector combined with a high performance liquid chromatograph were applied to the analysis of m-tyrosine, p-tyrosine and phenylalanine in normal human plasma. The mean value of plasma m-tyrosine, which was previously detected in mammals, was .apprx. 0.28 .+-. 0.05 .mu.g/ml. The mean plasma concentrations of p-tyrosine (9.82 .+-. 1.11 .mu.g/ml) and phenylalanine (7.34 .+-. 1.47 .mu.g/ml) were in good accord with values reported by other authors.