Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy.
Open Access
- 1 January 1987
- journal article
- research article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 46 (1), 42-45
- https://doi.org/10.1136/ard.46.1.42
Abstract
The accumulation of chloroquine and hydroxychloroquine in unfractionated mononuclear cells and in purified monocytes, lymphocytes, and neutrophil polymorphonuclear leucocytes (PMN) was measured in vitro. Accumulation of both drugs in leucocytes was time and dose dependent. Cellular levels comparable to those found during antirheumatic therapy were achieved by preincubation for 60 minutes with up to 0.1 mM chloroquine or hydroxychloroquine.This publication has 15 references indexed in Scilit:
- CHLOROQUINE INHIBITS ACCESSORY CELL PRESENTATION OF SOLUBLE NATURAL AND SYNTHETIC PROTEIN ANTIGENSActa Pathologica Microbiologica Scandinavica Series C: Immunology, 2009
- Antioxidant action of antimalarials.Annals Of The Rheumatic Diseases, 1986
- Chloroquine inhibits the production of a mononuclear cell factor by inhibition of lectin bindingArthritis & Rheumatism, 1984
- Chloroquine: its effect on leucocyte auto- and heterophagocytosis.Annals Of The Rheumatic Diseases, 1984
- Immunosuppressive potential of antimalarialsAmerican Journal Of Medicine, 1983
- Pharmacologic actions of 4-aminoquinoline compoundsAmerican Journal Of Medicine, 1983
- Animal toxicity and pharmacokinetics of hydroxychloroquine sulfateThe American Journal of Medicine, 1983
- Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.The Journal of cell biology, 1980
- Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: Apparent inhibition of receptor recyclingBiochemical and Biophysical Research Communications, 1980
- Discontinuous density gradient separation of human minonuclear leucocytes using percoll® as gradient mediumJournal of Immunological Methods, 1979