This is a report of a study done on 12 men with Klinefelter's syndrome, seven of whom were institutionalized. Each expressed feelings of inadequacy and inferiority because of the accompanying gynecomastia and testicular atrophy. All areas of living appear to be affected by these attitudes, but especially sexuality. Further, these feelings appear to have a profound effect on both the behavior patterns and the mental illnesses of these subjects. However, this study was unable to establish a statistical correlation between the degree of disturbance of secondary sexual characteristics and the severity of the concomitant psychopathological disorder.