Dilute sodium hydroxide and dilute acetic acid both hydrolyze gluten even at 0 °C., the reaction constant and temperature coefficient being greatest in dispersions in alkali. The reaction appears to be unimolecular in both reagents although it seems probable that neither of these can effect complete hydrolysis. No appreciable hydrolysis occurred in gluten dispersed in urea or sodium salicylate solutions, even after relatively drastic heat treatment.