Pharmacokinetics of 5-Fluorouracil

Abstract

The major difficulty in-using pharmacokinetic concepts for monitoring individual therapy with 5-fluorouracil is based on the mostly intracellular location of the active nucleotide metabolites of 5-fluorouracil with no clear correlation to plasma levels of the drug. In addition, the basic biochemical mechanism of ‘thymine-less cell death’ following inhibition of de novo thymidylate synthesis by 2′-deoxy-5-fluorouridine 5′-monophosphate (FdUMP) is poorly understood, and only some of the biochemical determinants of therapeutic response to 5-fluorouracil are known. Individualised therapy with 5-fhiorouracil requires an integrated approach which should include methods of pharmacokinetics and biochemical kinetics. 5-Fluorouracil stands as an example for most of the pyrimidine and purine metabolites to which similar considerations apply in monitoring of cancer chemotherapy.