Congenital Metastasizing Adrenal Cortical Carcinoma Associated with Cytomegaly of the Fetal Adrenal Cortex

Abstract

A case of metastasizing adrenal cortical carcinoma is reported in a 5-day-old infant in whom there was also extensive cytomegaly of the fetal adrenal cortex. The findings in this case may supply an important link in the pathogenesis or biologic progression of adrenal cortical carcinomas of infancy and childhood. Some support is furnished for the theory of Craig and Landing regarding the oncogenic potential of the cytomegalic cells of the fetal adrenal cortex.