Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors
Open Access
- 1 January 1989
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 32 (1), 72-76
- https://doi.org/10.1002/anr.1780320112
Abstract
We isolated a VH1 germline gene (Humhv 1263) that is closely related to the heavy chains of 2 human rheumatoid factors (RF), Bor and Kas. We also found that the 783 rearranged VH1 gene is actually 91–93% homologous to Bor and Kas, and it differs from a VH1 complementary DNA (51P1) by only a single base. Thus, 783 is likely to be the unmutated form of a germline VH gene that may encode the heavy chains of RF Bor and Kas and several other human monoclonal RF.This publication has 16 references indexed in Scilit:
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