IgG AND IgA HEAVY CHAIN ALLOTYPES IN TYPE 1 DIABETES

Abstract
IgG and IgA H chain allotypes were determined in the sera of 483 Caucasian Type 1 diabetes patients and 503 Caucasian healthy controls. There was no significant difference between patients and controls neither on the level of Gm phenotype frequencies nor on the level of GM 3-locus and 2-locus haplotype frequencies. A selective IgA deficiency was found in 14 patients (2.9%) but in none of the control individuals (P < 10-4).