The effect of thyroid hormone on the high affinity Ca2+-ATPase in rat liver plasma membrane.
- 1 January 1984
- journal article
- research article
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 31 (2), 141-149
- https://doi.org/10.1507/endocrj1954.31.141
Abstract
The effect of thyroid hormone on the high affinity Ca2+-ATPase activity in rat liver plasma membrane was studied. The high affinity Ca2+-ATPase activity in plasma membrane was activated by 10-7 to 10-5 M of Ca2+ and was inhibited by 70 .mu.M trifluoperazine. Thyroidectomy of rats was associated with an increase in the activity of high affinity Ca2+-ATPase. The increased enzyme activity was normalized by T4 [thyroxine] administration to the animals. Na+-K+-ATPase activity in the membrane was decreased by thyroidectomy and the decreased enzyme activity was normalized by T4 administration. Apparently, thyroid hormone inhibits the Ca2+ extrusion system by inhibiting calmodulin-independent high affinity Ca2+-ATPase in liver plasma membrane.This publication has 5 references indexed in Scilit:
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