Regulation of neuropeptide Y (NPY) binding by guanine nucleotides in the rat cerebral cortex
Open Access
- 5 November 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 177 (1), 125-128
- https://doi.org/10.1016/0014-5793(84)80995-3
Abstract
In the presence of GTP, GDP, GMPP(NH)P, GMPP(CH2)P, GMPP(S)P but not in the presence of GMP, cGMP or ATP, the high affinity binding of neuropeptide Y (NPY) was reduced in a dose‐dependent manner. GTP (0.1 mM) diminished the maximal binding capacity for 125I‐labelled NPY by 40% without any change in the equilibrium dissociation constant of the receptor 125I‐labelled NPY complex.Keywords
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