Idiopathic Periosteal Hyperostosis with Dysproteinemia

Abstract

DURING the past five years we have encountered 2 unrelated children, a fourteen-year-old boy and a ten-year-old girl, affected by the same unusual syndrome. Both were brought to medical attention because of an acute febrile illness associated with severe pain in the extremities and inability to walk. Both children exhibited striking bone tenderness, accompanied by x-ray evidence of widespread subperiosteal new bone formation in the long bones. In both patients the most notable laboratory finding was a disturbance in the concentrations of various plasma proteins. Gradually, spontaneous clinical recovery occurred, and the radiographic and serum protein abnormalities disappeared. The etiology . . .