Reproductive Capacity of Mammalian Tumour Cells Irradiated in vivo with Cyclotron-produced Fast Neutrons
- 1 August 1965
- journal article
- research article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 38 (452), 613-617
- https://doi.org/10.1259/0007-1285-38-452-613
Abstract
The reproductive capacity of isologous P-388 leukemic cells has been determined in-vivo after irradiation with fast neutrons from the M. R. C. cyclotron, Hammersmith Hospital. When tumor-bearing donor animals are irradiated at 10 cm depth in tissue-equivalent phantom material, using a relatively narrow last neutron beam, the results are indistinguishable from results when donor animals are irradiated in air using a wide neutron beam. Implications of this finding for radiotherapy of human tumors are discussed.Keywords
This publication has 11 references indexed in Scilit:
- The Use of Threshold Detectors to Determine Changes in a Fast Neutron Energy Spectrum with Depth in a PhantomThe British Journal of Radiology, 1965
- A Method for Determining Dose-modification FactorsThe British Journal of Radiology, 1964
- A Fast-neutron Source for RadiotherapyNature, 1963
- Studies on Cell-survival of Irradiated Ehrlich Ascites TumourInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1961
- Effects of Different Ionizing Radiations on Human Cells in Tissue Culture: II. Biological ExperimentsRadiation Research, 1960
- The Dependence of RBE on the Energy of Fast Neutrons: 1. Physical Design and Measurement of Absorbed DoseRadiation Research, 1960
- Influence of Oxygen Tension on X-Ray-Induced Chromosomal Damage in Ehrlich Ascites Tumor Cells Irradiated in Vitro and in VivoRadiation Research, 1959