Mortality and Its Predictors among HIV Infected Patients Taking Antiretroviral Treatment in Ethiopia: A Systematic Review
Open Access
- 30 October 2017
- journal article
- review article
- Published by Hindawi Limited in AIDS Research and Treatment
- Vol. 2017, 1-10
- https://doi.org/10.1155/2017/5415298
Abstract
Background. Even though the benefit of antiretroviral therapy (ART) is well established, there is a regional variation in the extent of its benefit. The aim of this review is to highlight mortality and its predictors in Ethiopian adult HIV patients who were on ART. Methods. Relevant articles were searched on PubMed and Google Scholar databases. The search terms used in different combinations were predictor/determinant/factors, mortality/death/survival, HIV, ART/HAART, and Ethiopia. Result. 5–40.8% of the patients died during the follow-up period. More than half (50–68.8%) of the deaths occurred within 6 months of initiating ART. Advanced stage disease (stage III and stage IV), nonworking functional status (bedridden and ambulatory), low baseline CD4 count, low baseline hemoglobin level, TB coinfection, lower baseline weight, and poor treatment adherence were commonly identified as predictors of death in HIV patients. Conclusion. 5–40.8% of HIV patients in Ethiopia die in 2–5 years of initiating antiretroviral treatment. Most of the deaths in HIV patients occur early in the course of treatment. Special emphasis should be given for patients with advanced stage disease, nonworking functional status, low baseline CD4 count, low baseline hemoglobin level, TB coinfection, lower baseline weight, and poor treatment adherence.Keywords
This publication has 38 references indexed in Scilit:
- Survival on antiretroviral treatment among adult HIV-infected patients in Nepal: a retrospective cohort study in far-western Region, 2006–2011BMC Infectious Diseases, 2013
- Predictors of Mortality among Tuberculosis/HIV-Coinfected Persons in Southwest EthiopiaJournal of the International Association of Providers of AIDS Care (JIAPAC), 2013
- Mortality and its determinants among patients infected with HIV-1 on antiretroviral therapy in a referral centre in Yaounde, Cameroon: a retrospective cohort studyBMJ Open, 2013
- Causes of Death and Risk Factors for Mortality among HIV-Infected Patients Receiving Antiretroviral Therapy in KoreaJournal of Korean Medical Science, 2013
- Mortality in an antiretroviral therapy programme in Jinja, south-east Uganda: a prospective cohort studyAIDS Research and Therapy, 2011
- Improved antiretroviral treatment outcome in a rural African setting is associated with cART initiation at higher CD4 cell counts and better general health conditionBMC Infectious Diseases, 2011
- Antiretroviral treatment adherence and its determinants in Sub-Saharan Africa: a prospective study at Yaounde Central Hospital, CameroonAIDS Research and Therapy, 2009
- The effect of AIDS defining conditions on immunological recovery among patients initiating antiretroviral therapy at Joint Clinical Research Centre, UgandaAIDS Research and Therapy, 2009
- Predictors of mortality in HIV-infected patients starting antiretroviral therapy in a rural hospital in TanzaniaBMC Infectious Diseases, 2008
- Rapid Scale-up of Antiretroviral Therapy at Primary Care Sites in ZambiaJAMA, 2006