A PHARMACOLOGICAL APPROACH TO THE NATURE OF THE AUTOREGULATION OF THE RENAL BLOOD FLOW

Abstract

The dog''s kidney perfused with its own blood worked well in the autoregulation of blood flow. The autoregulation of renal blood flow was liable to diminish and disappear spontaneously and was abolished with the infusion of papaverine, theophylline, acetylcholine or norepinephrine. Dipyridamol, infused into the renal artery, restored the autoregulation of renal blood flow from the deprived state of spontaneous failure, but not from that induced by drugs. Its significance was discussed in relation to the adenine nucleotide metabolism of the renal blood vessels.