Nuclear Epoxide Hydrolase in the Human Fetal and Adult Liver
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 28 (6), 321-328
- https://doi.org/10.1159/000137980
Abstract
The epoxide hydrolase activity with styrene oxide as substrate was investigated in the nuclear fraction of human fetal and adult liver specimens. All investigated liver fractions catalyzed the hydration of styrene oxide and the average epoxide hydrolase activities were 0.37 and 1.90 nmol/min per mg protein in fetal and adult specimens, respectively. The enzyme followed Michaelis-Menten kinetics in fetal nuclear fraction and biphasic kinetics in adult livers. The nuclear/microsomal enzyme activity ratios of epoxide hydrolase were 0.09 and 0.11 for fetal and adult livers, respectively.This publication has 5 references indexed in Scilit:
- Glucuronidation of oxygenated benzo(a)pyrene derivatives by UDP-glucuronyltransferase of nuclear envelopeBiochemical and Biophysical Research Communications, 1981
- Epoxide hydrase and mixed-function oxidase activities of rat liver nuclear membranesArchives of Biochemistry and Biophysics, 1979
- DIFFERENCES BETWEEN NUCLEAR AND MICROSOMAL CYTOCHROME-P-450 IN UNINDUCED AND INDUCED RAT-LIVER1978
- ROLE OF MICROSOMES AND NUCLEAR-ENVELOPE IN METABOLIC ACTIVATION OF BENZO(A)PYRENE LEADING TO BINDING WITH NUCLEAR MACROMOLECULES1977
- HEPATIC MICROSOMAL EPOXIDE HYDRASE - SENSITIVE RADIOMETRIC ASSAY FOR HYDRATION OF ARENE OXIDES OF CARCINOGENIC AROMATIC-HYDROCARBONS1977