α‐Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling
- 31 August 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (24), 4611-4615
- https://doi.org/10.1016/j.febslet.2007.08.051
Abstract
Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was suppressed by pre-treating MM cells with alpha-tocopheryl succinate (alpha-TOS), which inhibited FGF2 secretion by inducing mitochondria-dependent generation of reactive oxygen species. The role of FGF2 was confirmed by its down-regulation by treating MM cells with siRNA, abolishing EC proliferation and wound healing enhancement afforded by MM cells. We conclude that alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling.Keywords
This publication has 20 references indexed in Scilit:
- A Peptide Conjugate of Vitamin E Succinate Targets Breast Cancer Cells with High ErbB2 ExpressionCancer Research, 2007
- Dietary Administration of the Proapoptotic Vitamin E Analogue α-Tocopheryloxyacetic Acid Inhibits Metastatic Murine Breast CancerCancer Research, 2006
- Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic SwitchCell Cycle, 2006
- Molecular mechanism of ‘mitocan’‐induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl‐2 family proteinsFEBS Letters, 2006
- Angiogenic and antiangiogenic gene therapyGene Therapy, 2005
- α-Tocopheryl Succinate Inhibits Malignant Mesothelioma byDisrupting the Fibroblast Growth Factor Autocrine LoopJournal of Biological Chemistry, 2005
- Clinical translation of angiogenesis inhibitorsNature Reviews Cancer, 2002
- FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibitionTrends in Pharmacological Sciences, 2001
- Inhibition of Angiogenesis and Vascular Tumor Growth by Interferon-Producing Cells: A Gene Therapy ApproachThe American Journal of Pathology, 2000
- Angiogenesis.Journal of Biological Chemistry, 1992