ELECTRON-MICROSCOPIC LOCALIZATION OF FACTOR-VIII-RELATED ANTIGEN IN ADULT HUMAN-BLOOD VESSELS
- 1 January 1982
- journal article
- research article
- Vol. 60 (3), 627-634
Abstract
Factor-VIII-related antigen was localized in adult human blood vessels using immunofluorescence and EM. In addition to its presence in endothelial cells, the antigen was localized within subendothelium and the layers of elastic lamina closest to the lumen. The 1st morphological evidence that factor-VIII-related antigen is associated with collagen fibrils within the vessel wall is provided. This subendothelial factor-VIII-related antigen may play a role in the adhesion of platelets to subendothelial components following endothelial injury.This publication has 7 references indexed in Scilit:
- BINDING OF FACTOR-VIII-VONWILLEBRAND FACTOR TO HUMAN ARTERIAL SUBENDOTHELIUM PRECEDES INCREASED PLATELET-ADHESION AND ENHANCES PLATELET SPREADING1981
- LOCALIZATION OF FACTOR-VIII-RELATED ANTIGEN IN HUMAN VASCULAR SUBENDOTHELIUM1980
- CORRECTION BY FACTOR-VIII OF IMPAIRED PLATELET-ADHESION TO SUBENDOTHELIUM IN VONWILLEBRAND DISEASE1978
- EFFECT OF SHEAR RATE ON PLATELET INTERACTION WITH SUBENDOTHELIUM IN CITRATED AND NATIVE BLOOD .1. SHEAR RATE-DEPENDENT DECREASE OF ADHESION IN VON WILLEBRANDS DISEASE AND BERNARD-SOULIER SYNDROME1978
- Platelet responses in health and diseaseMolecular and Cellular Biochemistry, 1978
- Cultured aortic endothelial cells from pigs with von Willebrand disease: in vitro model for studying the molecular defect(s) of the disease.Proceedings of the National Academy of Sciences, 1977
- Interaction of Collagen with the factor VIII antigen-activity - von Willebrand factor complexThrombosis Research, 1977