Food Intake, Weight Gain and Amino Acid Pools of Rats Receiving 1-Aminocyclopentane-1-Carboxylic Acid.

Abstract

Rats allowed diets containing 18% casein and 0.1%-aminocyclopentane-1-carboxylic acid (ACPC) ad libitum for a 3-day period exhibited significant decreases in food intake and growth rate as compared to rats given the basal diet. Significant reductions occurred in the levels of the amino acids in plasma, liver and muscle of rats receiving ACPC. When food intake was maintained by feeding with a stomach tube, no appreciable differences were found in growth rate or in the levels of the amino acids in the amino acid pools of rats injected intraperitoneally with 60 mg of ACPC as compared to rats injected with saline. It would appear that ACPC does not affect the distribution of amino acids in animal tissues or the growth rate when food intake is controlled.