A comparison of the hypothermic effects of methylphenidate and d-amphetamine
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in International Journal of Neuroscience
- Vol. 13 (2-3), 117-120
- https://doi.org/10.3109/00207458109043310
Abstract
Methylphenidate is a central nervous system stimulant with a spectrum of action similar to the effects of d-amph tamine. d-Amphetamine-induced hypothermia is mediated via release of dopamine in the DA meso-limbic pathway. Methylphenidate causes hypothermia among rats kept at 4°C, but d-amphetamine is twice as potent as methylphenidate. Dose-response relationship of mithylphenidate thermal effects exhibits a U-shape curve. The hypoth rmic effects of 5-15 mg/kg methylphenidate are mediated by central dopaminergic neurons, as pretreatment with haloperidol inhibits these effects. The hjpothsrmia produced by lar er doses of methylphenidate is not blocked by pretreatment with haloperidol and hypothermia induced by d-amphetamine is blocked by pretreatment with haloperidol.This publication has 12 references indexed in Scilit:
- Inhibition of [3H]dopamine accumulation in rat striatal synaptosomes by psychotropic drugsBiochemical Pharmacology, 1978
- On the Mode of Action of Central Stimulatory AgentsActa Pharmacologica et Toxicologica, 1977
- Methlphenidate-like effects of the new antidepressant drug nomifensine (HOE 984)European Journal of Pharmacology, 1976
- MethylphenidateSouthern Medical Journal, 1976
- The increase in brain tryptophan caused by amphetamine-like drugs: Correlation with an increase in body temperatureLife Sciences, 1976
- Effects of specific brain lesions on the thermal responses of rats to d-amphetamlneJournal of Neuroscience Research, 1976
- Brain 2-phenylethylamine as a major mediator for the central actions of amphetamine and methylphenidateLife Sciences, 1975
- Dopaminergic neurons in the nitro-striatal and mesolimbic pathways: Mediation of specific effects of d-amphetamineEuropean Journal of Pharmacology, 1975
- Release of Brain Dopamine as the Probable Mechanism for the Hypothermic Effect of D-AmphetamineNature, 1972