Assignment of the native Chinese hamster dihydrofolate reductase gene to chromosome 2
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 36 (4), 599-604
- https://doi.org/10.1159/000131982
Abstract
The native Chinese hamster DHFR gene was localized to 2pter^-ql4 using a combination of somatic cell hybrid technology and molecular techniques. In addition, PGD, ENOJ, and DTS, previously mapped to Chinese hamster chromosome 2, were localized to 2ql4— > qter. Localization of PGM1 to this region was confirmed. The relationship of the site of the native DHFR gene to the location of the homogeneously staining region in methotrexate-resistant cells is discussed.Keywords
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