Studies on the pink, adenine-deficient strains ofCandida albicans
- 1 January 1970
- journal article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 8 (1), 48-59
- https://doi.org/10.1080/00362177085190631
Abstract
Several pink or dark brown mutants of Candida albicans were obtained following exposure of the wild types to ultraviolet irradiation or ethyl methanesulfonate. Unlike the wild types, all the mutants required adenine and in addition the dark brown strain required valine and isoleucine for growth. The mutants accumulated the pigment in the cytoplasm either as localized granules or in a diffused form. They, however, did not differ from their parental strains in size and shape of yeast cells, fermentation and assimilation of sugars. Initially, the pink mutants were more resistant to amphotericin B, but upon passage on agar media for a prolonged period, they became as sensitive as the wild types. The pink strain produced less mycelium in vitro and in vivo, and were less virulent for mice, but more resistant to ultraviolet irradiation than the wild types.Keywords
This publication has 17 references indexed in Scilit:
- Enzymology of the pigmented adenine-requiring mutants of Saccharomyces and SchizosaccharomycesBiochemical and Biophysical Research Communications, 1969
- Functional blocks of the ad1 and ad2 mutants of Saccharomyces cerevisiaeBiochemical and Biophysical Research Communications, 1969
- Red pigment of adenine-deficient yeast Saccharomyces cerevisiaeBiochemical and Biophysical Research Communications, 1967
- The radiobiology of yeastRadiation Botany, 1965
- Promotion or retardation of the growth of adenine auxotrophs ofCandida albicans by purines, pyrimidines and nucleosidesAntonie van Leeuwenhoek, 1964
- Imidazole Compounds Accumulated by Purine Mutants of Neurospora crassaJournal of General Microbiology, 1961
- The Formation of Diazotizable Amine and Hypoxanthine by a Yeast: Possible Implications in the Biosynthesis of PurinesJournal of General Microbiology, 1954
- The Formation of Pigment and Arylamine by YeastsJournal of General Microbiology, 1952
- Mendelian Inheritance of Genes Affecting Vitamin-Synthesizing Ability in SaccharomycesAnnals of the Missouri Botanical Garden, 1947
- On an approximate method of determining the median effective dose and its error, in the case of a quantal responseEpidemiology and Infection, 1939