Effect of denervation and ouabain on the response of the resting membrane potential of rat skeletal muscle to potassium
- 1 March 1978
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 373 (3), 225-228
- https://doi.org/10.1007/bf00580828
Abstract
The effects of denervation and ouabain on the relationship between resting membrane potential (E M) and extracellular potassium concentration were determined for rat soleus (SOL) and extensor digitorum longus (EDL) muscles. At concentrations above 20 mM for both SOL and EDL fibres the relationship could be described adequately by the Nernst equation. Denervation resulted in reduction ofE M and a decrease in the slope of the relationship betweenE M and potassium concentration. 10−3 M ouabain produced the same effects as denervation. The results are discussed in relation to the alterations in membrane permeability previously shown to occur as a consequence of denervation. It is concluded that the lowE M of denervated muscle is the result of an increase in membrane permeability to sodium.Keywords
This publication has 16 references indexed in Scilit:
- In vitro studies of skeletal muscle membranesThe Journal of Membrane Biology, 1977
- Cation movements in normal and short‐term denervated rat fast twitch muscleThe Journal of Physiology, 1977
- K-contractures and membrane potential in mammalian skeletal muscleNature, 1977
- The membrane potential of rat diaphragm muscle fibres and the effect of denervation.The Journal of Physiology, 1976
- Effects of ouabain on denervated and dystrophic muscles of the mouseExperimental Neurology, 1975
- Contribution of an electrogenic sodium pump to membrane potential in mammalian skeletal muscle fibres.The Journal of Physiology, 1975
- Effect of local temperature on the resting membrane potential in rat muscleElectroencephalography and Clinical Neurophysiology, 1970
- Effect of cold on muscle potentials and electrolytesMetabolism, 1968
- Relation of resting potential of rat gastrocnemius and soleus muscles to innervation, activity, and the Na‐K pumpJournal of Experimental Zoology, 1967
- Resting Potential of Isolated Rat Muscles measured in PlasmaNature, 1963