Haem a, cytochrome c and total protein turnover in mitochondria from rat heart and liver
- 1 September 1970
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 119 (2), 157-160
- https://doi.org/10.1042/bj1190157
Abstract
Haem a and cytochrome c were isotopically labelled in mitochondria from rat heart and liver after injection of δ-amino[2,3-3H2]laevulate, a specific haem precursor. [guanido-14C]Arginine or l-[4,5-3H2]leucine were used to label mitochondrial proteins. Half-lives were measured from biological decay in vivo and were similar (5.5–6.2 days) for haem a, cytochrome c and [14C]arginine-labelled proteins. Labelling of hepatic mitochondrial proteins with [3H2]leucine resulted in a prolonged apparent half-life.Keywords
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