Control of Total Systemic Vascular Capacity by the Carotid Sinus Baroreceptor Reflex
- 1 July 1973
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 33 (1), 22-33
- https://doi.org/10.1161/01.res.33.1.22
Abstract
To attain a quantitative understanding of carotid sinus baroreceptor reflex control of cardiac output, we studied the reflex control of total systemic vascular capacity in vagotomized dogs. In experiments measuring blood volume shifts caused by the carotid sinus reflex (series 1), venous return was diverted into a reservoir while cardiac output and central venous pressure were maintained at constant levels. The pressure in the isolated carotid sinuses (ISP) was lowered or raised in 25-mm Hg steps between 75 and 200 mm Hg. This procedure mobilized blood into or out of the reservoir, indicating a decrease or an increase in total vascular capacity, respectively. The mean maximum volume shift, 3.6 ml/kg body weight, occurred in the same ISP region, 135 ± 12.5 mm Hg, where reflex control of total peripheral resistance was strongest. The total volume shift was approximately 7.5 ml/kg for ISP changes from 75 to 200 mm Hg. When mean arterial blood pressure was maintained constant during the ISP step changes, the volume shift almost doubled. In experiments measuring the reflex effect on total systemic vascular compliance (series 2) and in experiments determining the reflex control of arterial compliance (series 3), total systemic vascular and lumped arterial compliances were measured in the same dogs that were used in series 1 experiments. The total systemic vascular and arterial compliances were approximately 2.0 ml/mm Hg kg-1 and 0.0677 ml/mm Hg kg-1, respectively. The reflex did not affect these compliances. We concluded that the reflex controls the total systemic venous capacity to a degree that changes cardiac output potentially by 30-10% per 25-mm Hg change in ISP.Keywords
This publication has 9 references indexed in Scilit:
- Cardiac output and total peripheral resistance in carotid sinus reflexAmerican Journal of Physiology-Legacy Content, 1971
- MEAN CIRCULATORY PRESSURE IN CAROTID SINUS REFLEXThe Japanese Journal of Physiology, 1971
- Influence of carotid baroreceptors on different components of the vascular systemThe Journal of Physiology, 1969
- Role of the veins in the carotid sinus reflexAmerican Journal of Physiology-Legacy Content, 1966
- Veins and venous toneAmerican Heart Journal, 1964
- Influence of Carotid Baroreceptors and Vasoactive Drugs on Systemic Vascular Volume and Venous DistensibilityCirculation Research, 1961
- Pressure-Volume Curves of the Arterial and Venous Systems in Live DogsAmerican Journal of Physiology-Legacy Content, 1956
- Venous Return as Affected by Cardiac Output and Total Peripheral ResistanceAmerican Journal of Physiology-Legacy Content, 1953
- Zur Kenntnis des CarotissinusreflexesZeitschrift für Die Gesamte Experimentelle Medizin, 1926