Glutathione Peroxidase Blockage Inhibits Prostaglandin Biosynthesis in Rat Platelets and Aorta
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 13 (4), 240-243
- https://doi.org/10.1159/000214754
Abstract
In the present study we demonstrated that the compound 3-amino-l,2,4-triazole (AMT) is a strong inhibitor of erythrocyte glutathione peroxidase (GSH-Px) activity. Moreover, AMT inhibits arachidonic-induced malondialdehyde formation in platelet-rich plasma and prostacyclin-like activity generation in aorta rings. These results give new lines of evidence on the connection between GSH-Px activity and prostaglandin synthesis in rat platelets and arterial vessel wall.Keywords
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