THE EFFECTS OF RENIN ON RENAL BLOOD FLOW AND GLOMERULAR FILTRATION

Abstract

Slow intraven. infusion of renin, either highly purified, or prepared by methods other than those of Helmer and Page (1939) into uninephrectomized dogs with single explanted kidneys, or dogs both of whose kidneys were subcut. explanted, resulted, in 22 of 24 expts., in decreased renal blood flow and increased renal extraction of inulin from blood. Arterial pressure was increased in every instance. Renal blood flow increased slightly in 2 expts. The decrease of renal blood flow was proportional to the degree of constriction of glomerular efferent arterioles, as measured by renal extraction of inulin, but was not proportional to the increase in arterial pressure.