Abstract
Postexposure chemoprophylaxis is now recommended for health care workers who experience certain kinds of occupational exposures to the human immunodeficiency virus (HIV) in the workplace. Substantial information has emerged that supports but does not prove the efficacy of antiretroviral agents in preventing HIV infection after occupational exposure. This article reviews the data that have accrued in the past 8 years that bear directly on this question and describes a systematic approach to the clinical management of health care workers occupationally exposed to HIV.

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