Thermospray Liquid Chromatographic--Mass Spectrometric Analysis of Castanospermine-Related Alkaloids in Castanospermum australe
- 1 March 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 53 (2), 359-365
- https://doi.org/10.1021/np50068a014
Abstract
Crude sample solution prepared from the seeds of Castanosperum australe was fractionated by preparative liquid chromatography. The fractions thus obtained were subsequently analyzed by means of thermospray liquid chromatography-mass spectrometry (tsp lcms). Under the conditions employed, castanospermine [1], 6-epi-castanospermine [2], australine [3], 3,8-di-epi-alexine [4], and fagomine [5] could be separated and detected. The possible structures of other castanospermine-related alkaloids found in the crude sample solution are also discussed.Keywords
This publication has 12 references indexed in Scilit:
- AUGMENTATION OF MURINE NATURAL-KILLER CELL-ACTIVITY BY SWAINSONINE, A NEW ANTIMETASTATIC IMMUNOMODULATOR1988
- INHIBITION OF V-FMS-INDUCED TUMOR-GROWTH IN NUDE-MICE BY CASTANOSPERMINE1988
- Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.Proceedings of the National Academy of Sciences, 1987
- Antiretroviral activity of castanospermine and deoxynojirimycin, specific inhibitors of glycoprotein processingBiochemical and Biophysical Research Communications, 1987
- 6-Epicastanospermine, a novel indolizidine alkaloid that inhibits α-glucosidaseArchives of Biochemistry and Biophysics, 1986
- Optimization and application of thermospray high-performance liquid chromatography/mass spectrometryAnalytical Chemistry, 1985
- Glycosidase inhibition by plant alkaloids which are structural analogues of monosaccharidesPhytochemistry, 1985
- Studies on the mechanism of castanospermine inhibition of α- and β-glucosidasesArchives of Biochemistry and Biophysics, 1984
- Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed ( Astragalus lentiginosus )Science, 1982
- Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australePhytochemistry, 1981