Opiate antagonist WIN44, 441–3 stereospecifically improves neurologic recovery after ischemic spinal injury
- 1 September 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 35 (9), 1311
- https://doi.org/10.1212/wnl.35.9.1311
Abstract
In the unanesthetized rabbit, temporary aortic occlusion results in predictable patterns of spinal cord injury. We use this "spinal stroke" model to assess the potential role of opiate antagonists in treating CNS ischemia. WIN44, 441–3 (WIN( —)), an opiate antagonist with enhanced activity at the K-receptor, reduced motor dysfunction after ischemic spinal cord injury. The effect was stereospecific and dose-related; beneficial actions were seen at doses as low as 40 μg/kg. Opiate receptor antagonists may be therapeutically useful in ischemic CNS injury, and the beneficial actions of these compounds may be at the K-receptor site.This publication has 12 references indexed in Scilit:
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