Staudinger Ligation: A Peptide from a Thioester and Azide
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- 1 June 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (13), 1939-1941
- https://doi.org/10.1021/ol0060174
Abstract
The technique of native chemical ligation enables the total chemical synthesis of proteins. This method is limited, however, by an absolute requirement for a cysteine residue at the ligation juncture. Here, this restriction is overcome with a new chemical ligation method in which a phosphinobenzenethiol is used to link a thioester and azide. The product is an amide with no residual atoms.Keywords
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