Thyroid-Hormone Enhancement of Imipramine in Nonretarded Depressions
- 7 May 1970
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 282 (19), 1063-1067
- https://doi.org/10.1056/nejm197005072821903
Abstract
The speed and efficacy of imipramine in the treatment of clinical depression was enhanced by the addition of tri-iodothyronine to the treatment program. L-tri-iodothyronine, 25 μg daily, added to imipramine, 150 mg per day, significantly improved performance on the Hamilton Rating Scale and the Self-rating Depression Scale as compared to that in patients receiving imipramine and a placebo. Morbidity and duration of hospitalization were diminished. The patients were euthyroid according to conventional clinical and laboratory criteria. The hormone quickened ankle reflex time and suppressed levels of protein-bound iodine. These physiologic changes, though definite, were slight and within the limits of euthyroidism as usually defined.Keywords
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