DOPAMINERGIC ACTIVITY OF SOME APOMORPHINE ANALOGS
- 1 January 1976
- journal article
- research article
- Vol. 15 (1), 89-106
Abstract
The dopaminergic activity of 10 apomorphine analogs was studied in rats lesioned unilaterally with 6-hydroxydopamine in the nigro-striatal system. N,N-dimethyl-5,6-dihydroxy-2-aminotetralin (M-7), N-methyl-5,6-dihydroxy-2-aminotetralin (M-8) and N,N-dimethyl-4,5-dihydroxy-2-aminoindan (DDAI) exhibited potent dopaminergic stimulant activity by causing the rat to turn to the unoperated side. The turning behavior of apomorphine, M-7, DDAI and d-amphetamine were antagonized by haloperidol. M-7 and DDAI also induced pecking in pigeons and their effects were also blocked by haloperidol. M-7, M-8 and DDAI are direct acting central dopaminergic agents.This publication has 3 references indexed in Scilit:
- Dopaminergic nature of amphetamine-induced pecking in pigeonsEuropean Journal of Pharmacology, 1975
- INHIBITION OF SYMPATHETIC NERVOUS-SYSTEM BY 5,6-DIHYDROXY-2-DIMETHYLAMINO TETRALIN (M-7), APOMORPHINE AND DOPAMINE1975
- Mode of action of apomorphine and dexamphetamine on gnawing compulsion in ratsPsychopharmacology, 1967