Androgen Administration in the Postmenopausal Woman

Abstract

Cyclic admn. of testosterone propionate at dosage levels of from 10 to 100 mg. daily for 10 days to estrogen-primed postmenopausal women caused withdrawal bleeding and produced progestational changes in the endometria. Testosterone was 8-10 times less effective in causing withdrawal bleeding and 10-20 times less effective than progesterone. Masculinization was not noted in these patients until the 100 mg. daily level was reached and this dosage level also caused transient vertigo accompanied by a lowered blood pressure in many cases.