Lesions of Rat Infralimbic Cortex Enhance Recovery and Reinstatement of an Appetitive Pavlovian Response
Open Access
- 1 September 2004
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 11 (5), 611-616
- https://doi.org/10.1101/lm.79704
Abstract
The prefrontal cortex (PFC) has a well-established role in the inhibition of inappropriate responding, and evidence suggests that the infralimbic (IL) region of the rat medial PFC (MPFC) may be involved in some aspects of extinction of conditioned fear. MPFC lesions including, but not those sparing the IL cortex increase spontaneous recovery of extinguished conditioned fear when tested 24 h after an initial extinction session. The current experiment extended these findings by use of appetitive rather than aversive conditioning. Ten IL-lesioned and 11 sham-operated rats were trained on a Pavlovian task in which a conditioned stimulus (CS) was followed by food pellets (the unconditioned stimulus or US). IL lesions had no effect on extinction of the conditioned response (CR, magazine entries) during the first extinction session. However, the level of spontaneous recovery between the first extinction session and a second, 24 h later, was increased in IL-lesioned rats relative to sham animals. In contrast, evidence of savings measured between the extinction sessions did not differ between groups. Furthermore, reinstatement of the CR following unsignaled delivery of the US was also increased in IL-lesioned rats.Keywords
This publication has 19 references indexed in Scilit:
- Neurons in medial prefrontal cortex signal memory for fear extinctionNature, 2002
- Interactions of prefrontal cortex during eyeblink conditioning as a function of ageNeurobiology of Aging, 2001
- Retraining of extinguished Pavlovian stimuli.Journal of Experimental Psychology: Animal Behavior Processes, 2001
- Prelimbic cortex specific lesions disrupt delayed-variable response tasks in the rat.Behavioral Neuroscience, 1996
- Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.Behavioral Neuroscience, 1995
- Involvement of subdivisions of the medial prefrontal cortex in learned cardiac adjustments in rabbits.Behavioral Neuroscience, 1994
- Involvement of subdivisions of the medial prefrontal cortex in learned cardiac adjustments in rabbits.Behavioral Neuroscience, 1994
- Inhibitory associations between S and R in extinctionLearning & Behavior, 1993
- Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.Psychological Bulletin, 1993
- Reinstatement of fear to an extinguished conditioned stimulus.Journal of Experimental Psychology: Animal Behavior Processes, 1975