Platelet-aggregating activity of type I and type III collagens from human aorta and chicken skin
- 15 December 1976
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 160 (3), 647-651
- https://doi.org/10.1042/bj1600647
Abstract
Human or chicken type III collagen dissolved in 0.1 M-acetic acid was much more potent than type I collagen at inducing platelet [human] aggregation. After incubation in 0.38 M-Na2HPO4 to promote fibrillogenesis, the platelet-aggregating activity of both collagen types increased, and type I was then virtually equiactive with type III. Preincubation in cell-free plasma increased the activity of chicken but not that of human collagen. The platelet-aggregating activity of type III collagen did not appear to depend on the integrity of the intrachain disulfide bonds.This publication has 17 references indexed in Scilit:
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