Small doses (0.5 × 10––8 and 1.0 × l0––8 mol) of bradykinin were administered intracamerally to rabbit eyes undergoing closed circuit perfusion with Krebs’ saline. The response consisted of intense miosis and a sharp rise of intraocular pressure accompanied by an increase in the amount of protein appearing in the effluent. There was no significant increase prostaglandin-like activity in the effluent and the response was not abolished by the addition of indomethacin (100 μg/ml) or atropine (8 × 10––6 g/ml) to the perfusate