CELLULAR HETEROGENEITY IN THE PRODUCTION OF AN ANTI-HAPTEN ANTIBODY
Open Access
- 1 July 1967
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 126 (1), 159-170
- https://doi.org/10.1084/jem.126.1.159
Abstract
Single lymph node cells from rats immunized with a conjugate of 3-iodo-4-hydroxy-5-nitrophenyl acetic acid chloride (NIP) and chicken globulin were tested against either NIP or NNP conjugated with bacteriophage. NNP is related to NIP but has a nitro group instead of iodine. The conjugated phages were still infective but easily inactivated by anti-hapten sera at a serum concentration of 10–7. Phages carrying a related hapten were less sensitive to antibody than phages conjugated with the immunogenic hapten.This publication has 11 references indexed in Scilit:
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