Antianginal Effect of Nifedipine after Intracoronary and Intravenous Administration Judged by Reduction of Ischemic ST-Segment Depression in Exercise Tests

Abstract

The peripheral and the cardiac modes of action of nifedipine [in humans], a drug which inhibits transmembrane Ca transport, were distinguished. To assess the cardiac and peripheral antianginal effect independently, 2 routes of application were employed: systemic i.v. and intracoronary infusion into the left coronary artery of approximately equipotent doses.