Transitional Myeloproliferative Disorder
- 1 October 1979
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 43 (2), 167-184
- https://doi.org/10.1111/j.1365-2141.1979.tb03739.x
Abstract
Summary. Eleven patients have been observed with clinical features of both polycythaemia vera and myelofibrosis. Detailed follow‐up and repeated haematological and isotopic investigations, including the assessment of erythropoietic distribution by 52Fe scanning, over a 10 year period, have indicated that patients who initially present with this syndrome may remain in a steady state for several years and that this transitional syndrome does not necessarily imply an active or irreversible transformation into classical myelofibrosis. Therapy with iron, folic acid, alkylating agents, splenectomy or splenic irradiation may reduce the extramedullary component of myeloproliferation and allow occasional patients to revert to more classical polycythaemia vera. Radioactive phosphorus (32P) therapy may be inappropriate in polycythaemic patients with dominant extramedullary erythropoiesis, as this form of therapy has a preferential medullary action and may selectively encourage extramedullary myeloproliferation.This publication has 22 references indexed in Scilit:
- Polycythaemia Vera — Transformation to Myelofibrosis and Subsequent ReversalScandinavian Journal of Haematology, 1978
- Chronic Idiopathic Myelofibrosis. A Reversible Disease?Acta Haematologica, 1977
- Quantitative Studies of Splenic Erythropoiesis in Polycythaemia Vera and MyelofibrosisBritish Journal of Haematology, 1976
- Erythrokinetic Studies as a Guide to the Value of Splenectomy in Primary Myeloid MetaplasiaBritish Journal of Haematology, 1973
- The effect of radiation on splenic function in myelosclerosis: studies with52Fe and99TcmThe British Journal of Radiology, 1973
- Studies of Splenic Function in the Myeloproliferative Disorders and Generalized Malignant LymphomasBritish Journal of Haematology, 1971
- The Haematological Complications of Polycythaemia Vera and Treatment with Radioactive PhosphorusThe British Journal of Radiology, 1966
- POLYCYTHEMIA VERA AND LEUKEMIA—THE ROLE OF RADIATION TREATMENTMedicine, 1965
- Human Bone Marrow Distribution Shown in vivo by Iron-52 and the Positron Scintillation CameraScience, 1964
- Use of Iron-52 as a Radioactive TracerNature, 1958