Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides.
Open Access
- 1 September 1992
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 176 (3), 915-918
- https://doi.org/10.1084/jem.176.3.915
Abstract
A synthetic tetrasaccharide structurally related to blood groups and selectin ligands inhibited division of astrocytes, gliomas, and neuroblastomas at micromolar concentrations. The compound was cytostatic for primary astrocytes in culture, but cytotoxic for fast proliferating cell lines.Keywords
This publication has 13 references indexed in Scilit:
- Synthesis of oligosaccharide inhibitors of neural cell divisionCarbohydrate Research, 1992
- Sweetening the selectin potCurrent Biology, 1991
- Sticky sugars for selectinsNature, 1991
- Recognition by Elam-1 of the Sialyl-Le x Determinant on Myeloid and Tumor CellsScience, 1990
- Antigenic and functional characterization of a rat central nervous system-derived cell line immortalized by a retroviral vector.The Journal of cell biology, 1988
- Astrocyte Mitogen Inhibitor Related to Epidermal Growth Factor ReceptorScience, 1988
- Distribution of anti-Leu-7, anti-Leu-11a and anti-Leu-M1 immunoreactivity in the brain of the adult ratCell and tissue research, 1987
- An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide.Journal of Histochemistry & Cytochemistry, 1985
- SIALYLATED LEWISx ANTIGEN DETECTED IN THE SERA OF CANCER PATIENTSThe Lancet, 1984
- Surface Glycoproteins of Normal and Transformed Cells: A Difference Determined by Sialic Acid and a Growth-Dependent Sialyl TransferaseProceedings of the National Academy of Sciences, 1972