Effect of Neomycin on Serum Cholesterol Level of Man.

Abstract

Summary Oral administration of neomycin was associated with a significant decrease in serum cholesterol concentration of all of the 10 patients studied. On 1.5 to 2 g of neomycin daily, mean serum cholesterol level in each patient was decreased from 17 to 29%, average fall for the group was 22%. The fall in serum cholesterol level was maintained for the duration of drug administration which varied from 3 to 16 weeks. At a daily dose level of 0.5 to 1 g of neomycin similar but less marked falls in the serum cholesterol level resulted.