Frequency-Specific Relation between Hippocampal Theta Rhythm, Behavior, and Amobarbital Action
- 5 June 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3936), 1246-1248
- https://doi.org/10.1126/science.168.3936.1246
Abstract
The frequency of the hippocampal theta rhythm in freely moving rats varies predictably in relation to behavior in a simple learning situation. The theta rhythm may be driven by electrical stimulation of the medial septal area at frequencies within the theta range. The threshold for septal driving is lowest at that frequency which the rat displays in response to frustrative nonreward; the driving threshold is selectively raised at this frequency by sodium amobarbital. It is suggested that the behavioral effects of amobarbital are due to a disruption of the theta frequency normally displayed in response to nonreward.Keywords
This publication has 8 references indexed in Scilit:
- Possible inhibitory functions of the hippocampusNeuropsychologia, 1969
- Sodium amobarbital and effects of frustrative nonreward.Journal of Comparative and Physiological Psychology, 1969
- Hippocampal correlates of consummatory and observed behaviorPhysiology & Behavior, 1968
- Spectral analysis of low frequency components in the electrical activity of the hippocampus during learningElectroencephalography and Clinical Neurophysiology, 1967
- The effects of amobarbital sodium on differential instrumental conditioning and subsequent extinctionPsychopharmacology, 1967
- The hippocampus and behavior.Psychological Bulletin, 1967
- Drug Action on The Electrical Activity of The HippocampusInternational Review of Neurobiology, 1965
- Frustrative nonreward in partial reinforcement and discrimination learning: Some recent history and a theoretical extension.Psychological Review, 1962