Prior to July 1, 1967, 325 patients had selective coronary arteriography in our laboratory, using exclusively a brachial arterial dissection or Sones' technique. During the following 19 months, 515 selective coronary angiographies were performed percutaneously. The transaxillary approach was used in 15 cases as an elective procedure; 500 cases were done using a percutaneous femoral artery approach. During the same period, only 25 patients had selective coronary arteriography by brachial arteriotomy or Sones' technique. Because of the ease and rapidity of the approach and cannulation of the coronary arteries with the use of preformed polyethylene catheters, the percutaneous femoral technique is the method of choice for selective coronary arteriography. The procedure requires very little manipulation and can be usually completed in less than 30 minutes. The risk of complications is small when certain precautions previously outlined are observed. The technical quality of the examination is enhanced by the stability of the catheter in the coronary ostium, the high selectivity of the injections, and the possibility of obtaining lateral and marked oblique projections of the coronary arteries in rapid succession.