Chlorimipramine therapy for obsessive-compulsive neurosis

Abstract

Patients (20) with a history of treatment-resistant obsessional neurosis underwent a 4-wk clinical trial of chlorimipramine. Scores on the Psychiatric Questionnaire for Obsessive Compulsive Neurosis, the Leyton Obsessional Inventory, and 3 self-assessments indicated that there was no significant change in obsessive ruminations, obsessive rituals, horrific temptations or pervading doubt, but there was a substantial improvement in the obsessive symptom item, severity of obsessions, anxiety, depression and phobia. Side effects were mild. Chlorimipramine may be the most promising treatment for obsessive-compulsive neurosis.