Long-term synapse loss induced by focal blockade of postsynaptlc receptors
- 1 December 1994
- journal article
- Published by Springer Nature in Nature
- Vol. 372 (6506), 519-524
- https://doi.org/10.1038/372519a0
Abstract
Focal application in vivo of alpha-bungarotoxin to block neurotransmission in a small region of a neuromuscular junction causes long-lasting synapse elimination at that site. In contrast, blockade of neurotransmission throughout a junction does not cause synapse elimination. These and related experiments indicate that active synaptic sites can destabilize inactive synapses in their vicinity.Keywords
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