EXPERIMENTAL PANCREATIC CARCINOGENESIS .1. MORPHOGENESIS OF PANCREATIC ADENOCARCINOMA IN SYRIAN GOLDEN-HAMSTER INDUCED BY "N-NITROSO-BIS(2-HYDROXYPROPYL)AMINE

Abstract

In a serial sacrifice experiment, outbred male Syrian golden hamsters were treated once weekly for life with s.c. injections of N-nitroso-bis(2-hydroxypropyl)amine (DIPN). The pancreas was examined by high resolution light (1-.mu. sections) and transmission electron microscopy. Early nonspecific changes in all pancreatic epithelial cellular elements were followed by a progressive proliferation of intra- and interlobular duct cells, with the development of multicentric foci of cystic and papillary cystic adenomas, intraductal carcinomas and invasive ductal neoplasms. These observations were consistent with a multistage morphogenesis of pancreatic adenocarcinoma of ductal origin.