Carcinogenicity in Mice of Mutagenic Compounds from a Tryptophan Pyrolyzate
- 17 July 1981
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4505), 346-347
- https://doi.org/10.1126/science.7244619
Abstract
The compounds 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole, which are potent mutagens in a tryptophan pyrolyzate, ar hepatic carcinogens when given orally to mice at concentrations of 200 parts per million in a pellet diet. Female mice showed higher susceptibilities to both compounds than male mice.Keywords
This publication has 12 references indexed in Scilit:
- Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beefCancer Letters, 1980
- In vitro transformation of hamster embryo cells with a glutamic acid pyrolysis productToxicology Letters, 1979
- Fractionation of a mutagenic principle from broiled fish by high-pressure liquid chromatographyCancer Letters, 1979
- Effects of temperature and time on mutagen formation in pan-fried hamburgerCancer Letters, 1979
- Formation of Mutagens in Beef and Beef Extract During CookingScience, 1978
- Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulinBiochemical and Biophysical Research Communications, 1978
- Isolation and structure determination of mutagenic substances in L-glutamic acid pyrolysate.Proceedings of the Japan Academy, Series B, 1978
- Malignant transformation in vitro by tryptophan pyrolysis products.Proceedings of the Japan Academy, Series B, 1978
- Isolation and structure determination of a mutagenic substance in L-lysine pyrolysate.Proceedings of the Japan Academy, Series B, 1978
- In vitro transformation of hamster embryo cells with tryptophan pyrolysis products.Proceedings of the Japan Academy, Series B, 1977